CYP2A6*4 allele gene high frequency associated with low-density lipoprotein cholesterol (LDL-C) among Javanese Indonesian smokers

The CYP2A6 gene, which codes the enzyme, has known to have ahigh polymorphism. This polymorphism could decrease, increase, or eliminate enzyme activity. CYP2A6*4 , an inactive allele, decreased One of enzyme-specific substrates is nicotine. allele decrease nicotine metabolism that causes high levels in blood. In addition, it caused increasing Low-Density Lipoprotein Cholesterol (LDL-C) by expanding lipolysis process. purpose this research was evaluate effect gene on LDL-C levels. Respondents study were 31 male Javanese smokers. analytic observational with a cross-sectional design. Polymerase chain reaction (PCR) methods use identification gene. shows high-frequency alleles among subject detected, frequency 93.55%. Furthermore, did not impact levels, Odd Ratio value 1.636 (P-Value = 0.737). conclusion, does significantly affect Indonesian